I am a recent fan of the comic series Gold Digger. The series follows Gina Diggers, an extreme archaeologist, as she searches for treasure and adventure in lost civilizations and other dimensions. She is accompanied by her were-cheetah sister and an assortment of bodyguards, pilots, scientists, family, and friends. The creator is a fan of rpgs as there are many in-jokes throughout the series. If you have never read Gold Digger you can read the first 199 issues for free online.
If I was going to run an rpg based in the Gold Digger universe, I would combine the FATE games Atomic Robo Role Playing Game and Unwritten. Atomic Robo is already based on a comic; one that is full of action and high-tech hi jinks. Thus is would cover the action part of the Gold Digger universe as well as the advanced technology. Unwritten is a game based in the Myst universe that is about exploration and awe-inspiring worlds. It would cover those aspects of the Gold Digger comics. Jam them together and you got yourself a Gold Digger campaign.